Digami study bmj online

Prognostic implications of hypoglycaemic ... - heart.bmj.com

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5/1/2009 · Objective: To explore if hypoglycaemic episodes during hospitalisation influence the subsequent prognosis in patients with diabetes and acute myocardial infarction. Design, setting and patients: Within the framework of the clinical trial DIGAMI 2 hypoglycaemic episodes (blood glucose <3.0 mmol/l with or without symptoms) were recorded in 1253 patients (mean age 68 years; 67% males) …

Prognostic implications of hypoglycaemic ... - heart.bmj.com

Diabetes mellitus, insulin-glucose infusion in acute ...

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9/1/2002 · Malmberg K. for the DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group. Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus .

Diabetes mellitus, insulin-glucose infusion in acute ...

MANAGEMENT OF CARDIOGENIC SHOCK ... - heart.bmj.com

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11/1/2002 · The incidence of cardiogenic shock in community studies has not decreased significantly over time. Despite decreasing mortality rates associated with increasing utilisation of revascularisation, shock remains the leading cause of death for patients hospitalised with acute myocardial infarction (MI). Although shock often develops early after MI onset, it is typically not diagnosed on hospital ...

MANAGEMENT OF CARDIOGENIC SHOCK ... - heart.bmj.com

Intense metabolic control by means of insulin in patients ...

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2/23/2005 · Aims Patients with diabetes have an unfavourable prognosis after an acute myocardial infarction. In the first DIGAMI study, an insulin-based glucose management improved survival. In DIGAMI 2, three treatment strategies were compared: group 1, acute insulin–glucose infusion followed by insulin-based long-term glucose control; group 2, insulin–glucose infusion followed by standard glucose ...

Intense metabolic control by means of insulin in patients ...

Is admission blood glucose concentration ... - bmjopen.bmj.com

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1/1/2012 · Objective To explore the relative association of admission blood glucose levels and antecedent diabetes on early and long-term survival in a contemporary UK population of patients with ST elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI). Design Retrospective cohort study based on the Myocardial Ischaemia National Audit Project dataset.

Is admission blood glucose concentration ... - bmjopen.bmj.com

DIGAMI 2—disappointment but not despair - McCallum - 2005 ...

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You have free access to this content DIGAMI 2—disappointment but not despair

DIGAMI 2—disappointment but not despair - McCallum - 2005 ...

relationship between glycaemic variability and ...

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11/9/2012 · Baseline characteristics of demographics, comorbidities, and medications at admission for the total DIGAMI 2 population in the original trial (n = 1253) and the present subset (n = 578) are described in Table 1. The mean age of the patients in the present study was 67.9 years, the body mass index was 28 kg/m 2, and the majority was males (69% ...

relationship between glycaemic variability and ...

Effect of intensive glucose lowering treatment ... - bmj.com

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7/26/2011 · Objective To determine all cause mortality and deaths from cardiovascular events related to intensive glucose lowering treatment in people with type 2 diabetes. Design Meta-analysis of randomised controlled trials. Data sources Medline, Embase, and the Cochrane database of systematic reviews. Study selection Randomised controlled trials that assessed the effect of intensive glucose lowering ...

Effect of intensive glucose lowering treatment ... - bmj.com

Validation of a glucose–insulin–potassium infusion ...

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These study algorithms, unlike the protocol used in this study, had no potassium supplement, and moreover, the DIGAMI used higher insulin concentrations. Similar to the present study the authors reported no sign of hypokalaemia and an acceptable number of hypoglycaemic events.

Validation of a glucose–insulin–potassium infusion ...

British Medical Journal - bmj.com

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The ISIS›2 (Second International Study of Infarct Survival) Collaborative Group. BMJ 1998;316:1337›43. 3 Wald DS. Perceived contraindications to thrombolytic treatment in acute myocardial infarction. A survey at a teaching hospital. J Accid Emerg Med 1998;15:329›31.

British Medical Journal - bmj.com

Endocrine emergencies | Postgraduate Medical Journal

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9/1/2004 · Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group. BMJ 1997; 314: 1512 –5.

Endocrine emergencies | Postgraduate Medical Journal

A one-year retrospective audit of the DIGAMI protocolThe ...

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Aim To assess the impact of post-MI diabetes-care upon changes in diabetes therapy and on cardiovascular risk factors.Patients and methods Retrospective audit of case notes of patients with diabetes who were treated according to the DIGAMI protocol following an acute MI and who had completed at least one year of follow-up (n=86).Results A majority of patients continued insulin …

A one-year retrospective audit of the DIGAMI protocolThe ...

Short-term mortality of myocardial ... - jech.bmj.com

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9/1/2002 · Aim: The hypothesis that patients with hyperglycaemia during admission, regardless of previous diagnosis of diabetes, have worse prognosis than those with normal glucose values is controversial. The objective was to assess the role of hyperglycaemia on short-term mortality after myocardial infarction (MI). Methods and Results: A cohort study nested in a prospective registry of MI …

Short-term mortality of myocardial ... - jech.bmj.com

Effectiveness and safety of metformin in ... - bmjopen.bmj.com

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1/1/2012 · Objective To evaluate the effectiveness and safety of metformin use in clinical practice in a large sample of pharmacologically treated patients with type 2 diabetes and different levels of renal function. Design Observational study between July 2004 and December 2010, mean follow-up 3.9 years. Setting Hospital outpatient clinics and primary care in Sweden.

Effectiveness and safety of metformin in ... - bmjopen.bmj.com

Old myocardial infarction - Explain Medicine

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MALMBERG K., NORHAMMAR A., WEDEL H., RYDEN L.. Glycometabolic State at Admission: Important Risk Marker of Mortality in Conventionally Treated Patients With Diabetes Mellitus and Acute Myocardial Infarction : Long-Term Results From the Diabetes and Insulin-Glucose Infusion in Acute Myocardial Infarction (DIGAMI) Study.

Old myocardial infarction - Explain Medicine

Intensive insulin therapy in hospitalised ... - ebm.bmj.com

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2/1/2012 · Commentary on: Kansagara D, Fu R, Freeman M, et al. Intensive insulin therapy in hospitalized patients: a systematic review. Ann Intern Med 2011;154:268–82. Hyperglycaemia occurs in about 38% of hospitalised patients and is associated with increased morbidity, mortality and excessive cost.1,–,3 Earlier randomised controlled trials (RCTs), which reported improved outcome in critically ill ...

Intensive insulin therapy in hospitalised ... - ebm.bmj.com

Intensification of Therapeutic Approaches Reduces ...

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2/1/2004 · OBJECTIVE —The myocardial infarction (MI) registry of the Academic Schwabing Hospital, Munich, investigates the hospital course of diabetic and nondiabetic patients with acute MI. The aim of this study was to improve quality care management and to compare hospital mortality and therapeutic approaches (i.e., PTCA, stenting, GPIIb/IIIa receptor antagonists, glucose-insulin infusion).

Intensification of Therapeutic Approaches Reduces ...

Effects of Intensive Glucose Lowering in Type 2 Diabetes ...

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Background Epidemiologic studies have shown a relationship between glycated hemoglobin levels and cardiovascular events in patients with type 2 diabetes. We investigated whether intensive therapy ...

Effects of Intensive Glucose Lowering in Type 2 Diabetes ...

BET 3 | Emergency Medicine Journal - emj.bmj.com

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8/1/2010 · All of the studies have shown that attempts at strict control of glucose are associated with a higher level of episodes of hypoglycaemia and some studies have suggested a worse outcome for the patients in the treatment arms. The NICE-SUGAR Study was an international, multi-centre study involving 6104 patients at 42 centres.

BET 3 | Emergency Medicine Journal - emj.bmj.com

Hyperglycaemia is associated with poor ... - thorax.bmj.com

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4/1/2006 · Background: Hyperglycaemia is associated with poor outcomes from pneumonia, myocardial infarction and stroke, but the effect of blood glucose on outcomes from acute exacerbations of chronic obstructive pulmonary disease (AECOPD) has not been established. Recent UK guidelines do not comment on measurement or control of blood glucose in AECOPD. A study was therefore undertaken …

Hyperglycaemia is associated with poor ... - thorax.bmj.com

The effect of metformin on cardiovascular ... - drc.bmj.com

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12/1/2015 · The DPP study group calculated that 64% of the effect of metformin treatment on cardiovascular risk reduction was caused by weight reduction.30 Fontbonne et al20 demonstrated in The BIGuanides and Prevention of Risks in Obesity (BIGPRO1) study that metformin treatment (850 mg twice daily) for 1 year resulted a weight reduction of 1.2 kg ...

The effect of metformin on cardiovascular ... - drc.bmj.com

Glucose management in critically ill adults and children ...

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6/10/2015 · Blood glucose management in people with acute myocardial infarction and critical illness has always attracted controversy. Compared with the era before 2001 when no attention was given to blood glucose management, DIGAMI-1 in 1995 and the first Leuven study in 2001 showed improved outcomes with strict control of blood glucose, thereby suggesting a causal association between hyperglycaemia …

Glucose management in critically ill adults and children ...

Efficacy and safety of two 5 day insulin ... - jnnp.bmj.com

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9/1/2009 · Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group. BMJ 1997; 314: 1512 – 15.

Efficacy and safety of two 5 day insulin ... - jnnp.bmj.com

Heart Failure: A Serious and Common ... - Clinical Diabetes

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4/1/2004 · In Brief Because of the cardiotoxic triad (diabetic cardiomyopathy, hypertension, and coronary artery disease), heart failure (HF) has an increased prevalence and worse prognosis in diabetic patients. Treatment of HF is directed to glycemic control and blockade of the renin-angiotensin and sympathetic nervous system, primarily with angiotensin-converting enzyme inhibitors and a combined α-/β ...

Heart Failure: A Serious and Common ... - Clinical Diabetes

Effects of Prandial Versus Fasting Glycemia on ...

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9/11/2008 · OBJECTIVE—Hyperglycemia and Its Effect After Acute Myocardial Infarction on Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus (HEART2D) is a multinational, randomized, controlled trial designed to compare the effects of prandial versus fasting glycemic control on risk for cardiovascular outcomes in patients with type 2 diabetes after acute myocardial infarction (AMI).

Effects of Prandial Versus Fasting Glycemia on ...

Inpatient management of diabetes: survey in ... - pmj.bmj.com

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10/1/2003 · Malmberg K for the DIGAMI (Diabetes Mellitus Insulin Glucose infusions in Acute Myocardial Infarction) study group. Prospective randomized study of intensive insulin treatment on long-term survival after acute myocardial infarction in patients with diabetes. BMJ 1997; 314: 1515 –21.

Inpatient management of diabetes: survey in ... - pmj.bmj.com

The Association of Diabetes and Glucose Control With ...

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Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group. BMJ 1997; 314: 1512 – 1515.

The Association of Diabetes and Glucose Control With ...

(PDF) Effects of intensive glucose control on platelet ...

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Downloaded from heart.bmj.com on December 1, 2011 - Published by group.bmj.com Acute coronary syndromes Effects of intensive glucose control on platelet reactivity in patients with acute coronary syndromes. ... Although a high blood glucose level is one of the most than in the DIGAMI-2 study (16 mg/dl), and this difference important prognostic ...

(PDF) Effects of intensive glucose control on platelet ...

Tight glycaemic control in acute ... - thorax.bmj.com

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4/1/2006 · A new standard of care? It is now clear that hyperglycaemia of even short duration can be associated with adverse outcome in the acutely ill. Thus, the hyperglycaemic state has been associated with increased mortality in patients undergoing cardiothoracic surgery or suffering acute myocardial infarction, in victims of major trauma and those sustaining brain injury, and in association with ...

Tight glycaemic control in acute ... - thorax.bmj.com

Tackling myocardial infarction - dtb.bmj.com

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3/1/2000 · Malmberg K for the DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group. Prospective randomised study of intensive insulin on long term survival after acute myocardial infarction in patients with diabetes mellitus BMJ 1997; 314: 1512 – 5.

Tackling myocardial infarction - dtb.bmj.com

bmj guide to diabetes mellitus - MAFIADOC.COM

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With the first Diabetes Mellitus Insulin-Glucose Infusion in Acute Myocardial Infarction (DIGAMI) study we implemented rigorous sugar control. With DIGAMI 2 we went back to what we did before! Sadia Khan, consultant cardiologist, Middlesex, England BMJ GUIDE TO DIABETES MELLITUS | 3

bmj guide to diabetes mellitus - MAFIADOC.COM

(PDF) E-BOOK: BMJ GUIDE TO DIABETES MELLITUS. FOR DOCTORS ...

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PDF | On Jun 4, 2013, Jose Mario de Oliveira and others published E-BOOK: BMJ GUIDE TO DIABETES MELLITUS. FOR DOCTORS WORLWIDE. Sabreena Malik, Matthew Billingsley, Charles Clark, and Jose Mario ...

(PDF) E-BOOK: BMJ GUIDE TO DIABETES MELLITUS. FOR DOCTORS ...

(PDF) BMJ Guide to Diabetes: for doctors worldwide

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BMJ Guide to Diabetes: for doctors worldwide. ... Results from the study showed that 3% of those screened were diagnosed with type 2 diabetes. ... (DIGAMI) study …

(PDF) BMJ Guide to Diabetes: for doctors worldwide

Feasibility of Insulin-Glucose Infusion in Diabetic ...

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9/1/1994 · OBJECTIVE To investigate the effect of insulin-glucose infusion on metabolic control and hypoglycemie episodes and its feasibility and safety in patients with diabetes and myocardial infarction (MI) compared with conventional treatment. RESEARCH DESIGN AND METHODS Of 327 patients with suspected acute MI, 158 were randomized to insulin-glucose infusion for at least 24 h and 169 …

Feasibility of Insulin-Glucose Infusion in Diabetic ...

Cardiovascular Safety of Oral ... - Clinical Diabetes

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4/1/2002 · In Brief This article reviews and dispels concerns about the potential cardiotoxicity of insulin and oral diabetes drugs, specifically the insulin secretagogues, in patients with type 2 diabetes. The authors focus on insulin and the sulfonylurea drugs but also briefly discuss meglitinide analogs.

Cardiovascular Safety of Oral ... - Clinical Diabetes

Intensified insulin-based glycaemic control after ...

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5/12/2014 · Intensified insulin-based glycaemic control after acute myocardial infarction in patients with diabetes and hyperglycaemia at admission had a long-lasting effect on longevity. Although the effect of glucose lowering might be less apparent with presently available, more effective lipid-lowering and blood-pressure-lowering drugs, improved glycaemic control might still be important for longevity ...

Intensified insulin-based glycaemic control after ...

High mean fasting glucose levels ... - jnnp.bmj.com

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12/1/2008 · Background: Hyperglycaemia has been related to poor outcome and delayed cerebral ischaemia (DCI) after aneurysmal subarachnoid haemorrhage (aSAH). Objective: This study aimed to assess whether in patients with aSAH, levels of mean fasting glucose within the first week predict poor outcome and DCI better than single admission glucose levels alone.

High mean fasting glucose levels ... - jnnp.bmj.com

Case Study: The Recipe for Diabetes Success in the ...

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1/1/2002 · N.D., a 48-year-old, obese, African-American man, was admitted to intensive care unit with crushing, substernal chest pain. This was associated with dizziness, nausea, vomiting, and diaphoresis. The electrocardiogram on admission revealed T wave inversions in the anterior and lateral leads. He ruled in for a myocardial infarction (MI) by serial cardiac enzymes.

Case Study: The Recipe for Diabetes Success in the ...

Glycometabolic State at Admission: Important Risk Marker ...

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Background—The Diabetes and Insulin-Glucose Infusion in Acute Myocardial Infarction (DIGAMI) study addressed prognostic factors and the effects of concomitant treatment and glycometabolic control in diabetic patients with myocardial infarction (AMI). Methods and Results—Of 620 diabetic patients with AMI, 306 were randomly assigned to a ≥24-hour insulin-glucose infusion followed by ...

Glycometabolic State at Admission: Important Risk Marker ...

Diagnosis, epidemiology and pathogenesis of diabetes ...

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Malmberg, K., Ryden, L., Efendic, S., et al (1995) Randomized trial of insulin–glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. Journal of the American College of Cardiology, 26, 57 – 65.

Diagnosis, epidemiology and pathogenesis of diabetes ...

Diabetes Mellitus Insulin Glucose Infusion in Acute ...

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To evaluate whether rapid improvement of metabolic control in diabetic patients with an insulin-glucose infusion decreases mortality and morbidity. Diabetic patients with AMI were randomized to continuous intravenous insulin infusion for 24 hours (started at 5 U/h) or until normoglycemia was ...

Diabetes Mellitus Insulin Glucose Infusion in Acute ...

Prospective randomised study of intensive insulin ...

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View This Abstract Online; Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group. ... Study Group. BMJ. 1997; 314(7093):1512-5 (ISSN: 0959-8138) Malmberg K.

Prospective randomised study of intensive insulin ...

Management of diabetes and acute coronary syndromes ...

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Diabetes is one of the leading risk factors for the development of acute coronary syndromes with an increased inherent risk for mortality and morbidity. Rather than the classic symptom of chest pain an atypical presentation or silent ischaemia is common. This atypical presentation can be attributed to the presence of autonomic neuropathy.

Management of diabetes and acute coronary syndromes ...

Improving Diabetes Care in the Hospital Using Guideline ...

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10/1/2001 · Improving glycemic control for inpatients with diabetes remains a formidable challenge. While the use of inadequate and nonphysiological insulin regimens is widespread, there are many potential barriers to improving physician and nursing hospital practices in this area. This article describes an integrated program that utilizes subcutaneous and intravenous insulin order forms incorporating ...

Improving Diabetes Care in the Hospital Using Guideline ...

The British Journal of Diabetes & Vascular Disease http ...

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sial study from Dundee claimed a reduction in mortality with i.v. insulin.1 The DIGAMI study examined the hypothesis that a high-dose i.v. insulin infusion followed by intensive s.c. insulin would reduce mortality following MI in people with diabetes. Methods Design DIGAMI …

The British Journal of Diabetes & Vascular Disease http ...
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