Gleevec iris study stroke

Nilotinib versus Imatinib for Newly Diagnosed Chronic ...

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In the International Randomized Study of Interferon and STI571 (IRIS; ClinicalTrials.gov number, NCT00006343), imatinib was associated with a superior response rate and improved progression-free ...

Nilotinib versus Imatinib for Newly Diagnosed Chronic ...

Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial ...

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Background—By its inhibitory effect on platelet-derived growth factor signaling, imatinib could be efficacious in treating patients with pulmonary arterial hypertension (PAH). Methods and Results—Imatinib in Pulmonary Arterial Hypertension, a Randomized, Efficacy Study (IMPRES), a randomized, double-blind, placebo-controlled 24-week trial, evaluated imatinib in patients with …

Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial ...

A case of subdural hematoma in patient with chronic ...

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A case of subdural hematoma in patient with chronic myeloid leukemia treated with high-dose imatinib mesylate. ... Imatinib mesylate (IM, Gleevec; Novartis, Switzerland) is a potent and selective tyrosine kinase inhibitor that acts on Bcr/Abl, the protein product of the Philadelphia chromosome. ... IM pharmacokinetic analysis in the IRIS study ...

A case of subdural hematoma in patient with chronic ...

Gleevec, the targeted cancer pill, delivers more good news ...

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12/9/2007 · "The news about Gleevec and the childhood leukemia study as well as the six-year IRIS study that shows there is no progression to advanced phase in …

Gleevec, the targeted cancer pill, delivers more good news ...

(PDF) Principal long-term adverse effects of imatinib in ...

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Principal long-term adverse effects of imatinib in patients with chronic myeloid leukemia in chronic phase. ... patients. 4 This led to an international prospective clinical study (IRIS) ...

(PDF) Principal long-term adverse effects of imatinib in ...

CML Patients Need Alternative to Imatinib - Medscape

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One Third of CML Patients Need Alternative to Imatinib. ... Even though the median follow-up of 38 months in their study was shorter than that in the IRIS study, the results were similar. In the ...

CML Patients Need Alternative to Imatinib - Medscape

Long-term effects of imatinib on cognition in chronic ...

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Long-term effects of imatinib on cognition in chronic myeloid leukaemia. ... A safety sub-study undertaken by the Australasian Leukaemia and Lymphoma Group (ALLG) identified a range of subtle ...

Long-term effects of imatinib on cognition in chronic ...

Five-Year CML Survival with Gleevec Reaches 95%: Page 2 of ...

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Of 553 patients originally randomized to Gleevec in the IRIS trial, 382 patients were still taking Gleevec at 60 months, and of these 368 (96%) had a complete cytogenetic response, according to the study.

Five-Year CML Survival with Gleevec Reaches 95%: Page 2 of ...

(PDF) Congestive heart failure is a rare event in patients ...

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A total of 16 patients received (all grades) occurring in 20.2% and 5.6% of patients at 2 and single-agent imatinib, while 6 received imatinib in combination 4 years, respectively, in the IRIS study.28 with other chemotherapeutic or biologic agents (3 with interferon In response to the original observation by Kerkela¨ et al, several and ...

(PDF) Congestive heart failure is a rare event in patients ...

Gleevec, the targeted cancer pill, delivers more good news ...

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PORTLAND, Ore. Gleevec, the targeted cancer pill that has saved more than 100,000 lives, now is saving more children with a dire leukemia, as well as preventing disease progression with long term use in adults with chronic myeloid leukemia. Data at this weekends meeting continues to show how much ...

Gleevec, the targeted cancer pill, delivers more good news ...

Dose Escalation of Imatinib in Chronic-Phase CML Patients

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Suboptimal response or treatment failure to standard-dose imatinib are relevant problems in chronic-phase CML patients, and some will benefit from ramping-up the dose.

Dose Escalation of Imatinib in Chronic-Phase CML Patients

Tyrosine kinase inhibitor associated vascular toxicity in ...

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12/4/2015 · Over a decade ago, the International Randomized Interferon vs. STI571 Study (IRIS) established the tyrosine kinase inhibitor (TKI) imatinib as the standard of care for chronic myeloid leukemia (CML) patients [].Thus, imatinib revolutionized the treatment and prognosis of CML, which transitioned from a disease which progressed to acute leukemia and death within a matter of years, to …

Tyrosine kinase inhibitor associated vascular toxicity in ...

Imatinib for CML Patients in Whom Interferon Has Failed

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Such patients might achieve durable remissions with imatinib therapy. Imatinib mesylate (Gleevec) is the current standard of care for patients with newly diagnosed chronic-phase chronic myeloid leukemia (CML); the randomized phase III IRIS study of imatinib versus interferon (IFN-α) plus cytarabine ...

Imatinib for CML Patients in Whom Interferon Has Failed

Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial ...

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Study-drug discontinuations were comparatively high in the present study compared with previous studies with imatinib for malignant diseases (12% to 44% in studies up to 24 months in duration). 30,31 The exact reasons for this observation are unknown, but potential causes may include effects of the underlying disease and comedications as well ...

Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial ...

Congestive heart failure is a rare event in patients ...

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8/15/2007 · A recent preclinical study suggested that imatinib may be cardiotoxic in some patients. We reviewed all reported serious adverse events of cardiac adverse events occurring in patients on clinical trials involving imatinib. Among 1276 patients enrolled, 22 (1.7%) were identified as having symptoms that could be attributed to systolic heart failure.

Congestive heart failure is a rare event in patients ...

CML Flashcards | Quizlet

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Imatinib 400 mg po daily Nilotinib 300 mg po BID Dasatinib 100 mg po daily All category 1 recommendations from NCCN After initiating therapy with imatinib (or like agent), the WBC should begin to fall within the first two weeks

CML Flashcards | Quizlet

Analysis of the potential effect of ponatinib on the QTc ...

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4/23/2013 · Cardiac dysfunction, particularly QT interval prolongation, has been observed with tyrosine kinase inhibitors approved to treat chronic myeloid leukemia. This study examines the effects of ponatinib on cardiac repolarization in patients with refractory hematological malignancies enrolled in a phase ...

Analysis of the potential effect of ponatinib on the QTc ...

Five-Year CML Survival with Gleevec Reaches 95%

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Nevertheless, while Gleevec showed a remarkable ability to contain CML, it has not been able to cure the disease, reported Brian Druker, M.D., of the Oregon Health and Science University here, and colleagues in the International Randomized Study of Interferon and ST1571 (IRIS).

Five-Year CML Survival with Gleevec Reaches 95%

Chronic Myelogenous Leukemia (CML): Practice Essentials ...

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In the present study, imatinib-induced cardiotoxic effects typically occurred in vitro or in rats at concentrations higher than that needed for clinical efficacy (5 μM). Additionally, treatment with imatinib in mice or rats did not induce transcriptomic changes related to direct oxidative stress, mitochondrial integrity, or the ATP pool.

Chronic Myelogenous Leukemia (CML): Practice Essentials ...

Imatinib does not induce cardiotoxicity at clinically ...

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The firstCP patients exposed to imatinib mesylate (IM) as first-line therapy have been treated since 2000 in the IRIS (International Randomized Study of Interferon and STI571) study [1 x 1 O'Brien, SG, Guilhot, F, Larson, RA et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia.

Imatinib does not induce cardiotoxicity at clinically ...

Long-term follow-up of de novo chronic phase chronic ...

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Gleevec Resistance ... (IRIS study), ≥3 log reduction in BCR‐ABL transcript compared to ... disturbance, tinnitus, stroke. 10/8/2011 12 Polycythemia Vera Laboratory Features • Increased absolute red blood cell mass • Erythrocytosis (7‐10,000,000/mm3)

Long-term follow-up of de novo chronic phase chronic ...

80 Frater Klco - dn3g20un7godm.cloudfront.net

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Novartis and Alcon are now positioned to capitalize on significant growth opportunities and focus resources on their respective businesses and strategic priorities. Read More. Story / Apr 08, 2019. Bringing gene therapy into focus. Dr. Botond Roska says we should keep our eyes on gene therapy.

80 Frater Klco - dn3g20un7godm.cloudfront.net

Global Novartis News Archive | Novartis

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For Patients and Families. The ClinicalTrials.gov Web site provides current information about clinical research studies to patients, their families and caregivers, health care professionals, and the public. Each study record includes a summary of the study protocol, including the purpose, recruitment status, and eligibility criteria. Study ...

Global Novartis News Archive | Novartis

For Patients and Families - ClinicalTrials.gov

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This document will highlight studies to be presented at the annual meeting of the American Society of Hematology. Some of these include, chronic myeloid leukemia, sickle disease and anemia.

For Patients and Families - ClinicalTrials.gov

ASH 2002 Abstract Highlights Part 1 | Newswise: News for ...

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Find information on health conditions, wellness issues, and more in easy-to-read language on MedlinePlus, the up-to-date, trusted health information site from the …

ASH 2002 Abstract Highlights Part 1 | Newswise: News for ...

MedlinePlus - Health Information from the National Library ...

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This invention provides methods to predict the likelihood of occurrence of the side effect of edema in patients treated with a drug including, but not limited to, a TKI, such as Imatinib or GLEEVEC™/GLIVEC®. The methods employed use gene expression profile comparisons and the determination of specific SNPs and in the IL-1β gene.

MedlinePlus - Health Information from the National Library ...

EP1554400A1 - Methods to predict edema as a side effect of ...

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Graft-versus-host disease (GVHD) is a potentially serious complication of allogeneic stem cell transplantation. During allogeneic stem cell transplantation, a patient receives stem cells from a donor or donated umbilical cord blood. The donated stem cells contain T-cells, which are a type of white blood cell that help protect the body by ...

EP1554400A1 - Methods to predict edema as a side effect of ...

Graft-Versus-Host Disease | Leukemia and Lymphoma Society

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or a pharmaceutically acceptable salt thereof, wherein each variable is as defined and described herein. Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful for treating a variety of diseases, disorders or conditions, associated with regulation of signaling pathways implicating IRAK kinases.

Graft-Versus-Host Disease | Leukemia and Lymphoma Society

US9751892B2 - IRAK inhibitors and uses thereof - Google ...

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ity. Treatment could be stopped prematurely in case of inaccept- Dose escalation and toxicity assessment and clinical efficacy. able toxicity, disease progression or patient refusal to continue the The study was conducted as a single-center, Phase I, dose-esca- study.

US9751892B2 - IRAK inhibitors and uses thereof - Google ...
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